Cannabinoids: CBD versus CBDH

Cannabis is truly a treasure trove of natural compounds with unique properties. With approximately 150 identified cannabinoids found in various cannabis strains, each one offers its own distinct effects and potential benefits. 

While tetrahydrocannabinol (THC) and cannabidiol (CBD) are the most well-known and researched cannabinoids, there are also other "minor" cannabinoids like cannabidivarin (CBDV), cannabigerol (CBG), and cannabinol (CBN) that are gaining attention. 

However, the exciting discoveries in the world of cannabinoids are far from over. In fact, researchers recently stumbled upon cannabidihexol (CBDH), a new cannabinoid with potential benefits.

In this article, we'll take a closer look at CBD and CBDH, including their chemical structures, potential effects, and current research, to help you better understand this new compound and its unique properties. Whether you're a CBD enthusiast or simply interested in cannabinoids, join us as we delve into the similarities and differences between CBD and CBDH.

What is CBD?

what is cbd?

CBD, or cannabidiol, is a naturally occurring compound found in cannabis plants, including hemp and marijuana. It is one of over 100 cannabinoids identified in cannabis, and it is known for its potential health benefits without the psychoactive effects commonly associated with THC (tetrahydrocannabinol), which is another prominent cannabinoid in cannabis. CBD has gained widespread attention for its potential therapeutic properties, including its ability to promote relaxation, reduce inflammation, alleviate pain, and support overall well-being. CBD is available in various forms, such as oils, tinctures, capsules, edibles, topicals, and more, and it is legal in many countries and states, although regulations may vary.

What is CBDH?

CBDH (cannabidihexol) is an intriguing cannabinoid that stands out due to its larger molecular structure, with six carbon atoms compared to the five carbon atoms found in CBD. This extra carbon atom makes CBDH an ideal bridge between CBD and CBDP, potentially allowing for a wider range of effects by interacting with cannabinoid receptors in a unique way.


Cbd research

The researchers behind the discovery of CBDH conducted experiments on mice to assess its effects, and the results were promising. CBDH exhibited a higher level of analgesic activity compared to CBD, indicating it may be a more effective cannabinoid for pain relief. While the research was carried out on mice, there are speculations about how these findings may translate to humans.

Interestingly, during the research, it was observed that CBDH exhibited strong analgesic properties at a dose of 2 mg per kg when administered intraperitoneally. However, the effect decreased at higher doses and was completely absent at 5 mg of CBDH. This suggests a biphasic effect, where CBDH's effects may vary depending on the dosage.


One intriguing aspect of CBDH is its origin, which remains unknown. Researchers were unable to identify the presence of CBGH (cannabigerol) in the cannabis plant, which is the precursor to all cannabinoids. This raises questions about where CBDH comes from, as its origin still remains a mystery.

How Does CBDH Relieve Pain?

cbd pain relief

CBDH has shown promising potential as a pain-reliever and pain-management option, with researchers speculating that its effects could be attributed to its activation of vanilloid receptors (TRPV1) that play a role in mediating pain, pain-perception, and body temperature. 

However, interestingly, at higher doses, CBDH may also have the ability to block CB1 and CB2 receptors, which are involved in the body's response to pain, potentially resulting in a loss of pain-relief effects. This suggests that CBDH's effects may be dose-dependent and further research is needed to fully understand its mechanism of action and optimal dosages for pain management.

The discovery of CBDH has opened up new possibilities in the world of cannabinoids, offering exciting insights into their potential effects and mechanisms of action. Further research is needed to fully understand the properties and potential therapeutic applications of this unique cannabinoid, and its discovery has added to the growing body of knowledge about the complex chemistry of cannabis.


CBD has a unique relationship with the endocannabinoid system as it does not directly bind to cannabinoid 1 (CB1) or cannabinoid 2 (CB2) receptors. Instead, CBD primarily interacts with other receptors such as serotonin (5-HT) receptors and vanilloid (TRPV1) receptors. Activation of serotonin receptors has been associated with anti-depressant and anti-anxiety effects in rodent test subjects, while vanilloid receptor activation has been linked to the mediation of pain-perception, inflammation, and body temperature.

With CBDH having a molecular structure that is similar to CBD (with a six-alkyl side chain compared to CBD's five-alkyl side chain), it is reasonable to assume that CBDH may act in a similar way. However, further research is needed to fully understand the specific effects and benefits of CBDH and how it interacts with the endocannabinoid system, as well as its potential differences from CBD in terms of its mechanism of action and therapeutic properties.

Where to Find CBDH Products?

where to buy cbd

In recent years, cannabis brands and manufacturers have expanded their focus beyond CBD and THC to other minor cannabinoids. And although CBDH is naturally found in regular cannabis products, it is not present in high percentages. As the cannabinoid has recently been discovered, It may take some time before we see CBDH isolated and formulated into products, but the prospects are exciting and eagerly anticipated.

In the meantime there are a plethora of CBD based products available to consumers. One of the easiest and convenient ways to consume CBD is the elon® by E1011 Labs. The device works with predosed, prefilled stelo™ that give users the optimal amount of CBD in each stick. Enjoy your CBD any time and anywhere with E1011 Labs.